<p>In this episode, I’m joined by Dr. Melanie Cree—physician-scientist, pediatric endocrinologist, and one of the leading researchers redefining how we understand and treat Polycystic Ovary Syndrome (PCOS). PCOS affects millions of women, yet it's still underdiagnosed, misunderstood, and often mistreated. Dr. Cree cuts through the confusion, offering a deeply scientific yet compassionate look at what’s really driving this complex condition—from insulin resistance and mitochondrial dysfunction to skeletal muscle quality and fertility trajectories across a woman’s lifespan.</p><p>We cover:</p><ul><li>Why PCOS isn’t a single disease—and what two phenotypes may explain the full picture</li><li>How muscle, liver, and fat interact in PCOS</li><li>The misunderstood role of testosterone, insulin, and SHBG in diagnosis</li><li>What muscle biopsies reveal about teenage girls with PCOS</li><li>Intramuscular fat, mitochondrial impairment, and the true cost of sedentary muscle</li><li>How early lifestyle and exercise interventions could change the future of PCOS care</li><li>What GLP-1 agonists and amino acid supplements might offer for treatment</li></ul><br><p>Whether you’re a clinician, patient, or advocate for women’s health, this episode will give you a whole new lens on PCOS—and why skeletal muscle may be the most overlooked (and powerful) organ in the conversation.</p><p><strong>Who is Dr. Melanie Cree?</strong></p><p>Dr. Melanie Cree is a board-certified pediatric endocrinologist and Associate Professor at the University of Colorado and Children’s Hospital Colorado, where she directs a leading multidisciplinary PCOS clinic. Her research bridges metabolic medicine and muscle physiology, with clinical trials exploring semaglutide, amino acid therapy, liver metabolism, and insulin resistance in adolescents.</p><p><strong>Forever Strong Summit 2025: </strong></p><p>The Forever Strong Summit is a live event on April 27, 2025 in Houston, TX, designed to help you build strength, resilience, and longevity from the inside out. Featuring top minds in medicine, military, and mindset, you’ll walk away with practical tools to upgrade your health, sharpen your focus, and take ownership of your life. Whether you're a clinician, athlete, or simply ready to step into your next level—this is where science meets action. Get your ticket now! <a href="https://drgabriellelyon.com/forever-strong-summit-2025/" rel="noopener noreferrer" target="_blank">https://drgabriellelyon.com/forever-strong-summit-2025/</a> </p><p><strong>This episode is brought to you by:</strong></p><ul><li>LMNT – Get your free LMNT Sample Pack with any purchase → <a href="https://drinklmnt.com/DRLYON" rel="noopener noreferrer" target="_blank">DrinkLMNT.com/DRLYON</a></li><li>Cozy Earth – Get up to 40% off with code DRLYON → <a href="https://cozyearth.com/DRLYON" rel="noopener noreferrer" target="_blank">cozyearth.com/DRLYON</a></li><li>OneSkin – Get 15% off with the code DRLYON at → <a href="https://oneskin.co/" rel="noopener noreferrer" target="_blank">OneSkin.co</a></li><li>Timeline Nutrition – Get 10% off → <a href="https://timeline.com/LYON" rel="noopener noreferrer" target="_blank">timeline.com/LYON</a></li></ul><br><p><strong>Find Dr. Melanie Cree at: </strong></p><p>University of Colorado - <a href="https://som.cuanschutz.edu/Profiles/Faculty/Profile/22449" rel="noopener noreferrer" target="_blank">https://som.cuanschutz.edu/Profiles/Faculty/Profile/22449</a></p><p><strong>Find me at:</strong></p><ul><li>Instagram: <a href="https://www.instagram.com/drgabriellelyon" rel="noopener noreferrer" target="_blank">@drgabriellelyon</a></li><li>TikTok: <a href="https://www.tiktok.com/@drgabriellelyon" rel="noopener noreferrer" target="_blank">@drgabriellelyon</a></li><li>Facebook: <a href="https://www.facebook.com/doctorgabriellelyon" rel="noopener noreferrer" target="_blank">facebook.com/doctorgabriellelyon</a></li><li>YouTube:<a href="https://www.youtube.com/@DrGabrielleLyon" ...></a></li></ul>