<p dir="ltr">GLP-1s have dominated the headlines, but the next wave of compounds is already here, and they’re changing the conversation on fat loss, performance, and longevity. In this episode, I break down the science behind four emerging therapies and why you need to know about them now.</p> <p dir="ltr">We cover how Afoglipron, the first oral non-peptide GLP-1, removes the barrier of injections while delivering results on par with semaglutide. You’ll hear why Teriparatide, originally used for osteoporosis, may reduce visceral fat and protect bone density at the same time. I also dive into Mazdutide, a dual GLP-1/glucagon agonist that suppresses appetite while boosting energy expenditure, and Tesofensine, a brain-targeting appetite suppressant with powerful effects on cravings.</p> <p dir="ltr">I share what the latest clinical data shows, the benefits and risks for both general populations and athletes, and how these compounds could fit into the bigger picture of training, nutrition, and longevity.</p> <p dir="ltr">This is a must-listen.</p> <p dir="ltr">What's Discussed:</p> <p dir="ltr">00:05 — Why GLP-1s have exploded and what’s next beyond semaglutide</p> <p dir="ltr">01:53 — Afoglipron: The first oral GLP-1 and why it’s a game changer</p> <p dir="ltr">07:16 — Teriparatide: Surprising fat loss potential in a bone health drug</p> <p dir="ltr">10:29 — Mazdutide: The “eat less, burn more” dual agonist</p> <p dir="ltr">13:17 — Tesofensine: Targeting food noise and cravings in the brain</p> <p dir="ltr">16:20 — Are these drugs the future of fat loss, or a Pandora’s box?</p> <p dir="ltr"><br> Thank you to our sponsors: <strong> </strong></p> <p dir="ltr" role="presentation">NAD + Cell Shield from Biostack Labs <a href="https://biostacklabs.com/kris">https://biostacklabs.com/kris</a> </p> <p dir="ltr" role="presentation">BiOptimizers - code KRIS10 for 10% off  <a href="https://bioptimizers.com/">https://bioptimizers.com/</a> </p> <p dir="ltr" role="presentation">Timeline: My friends at Timeline are offering 20% off, just for my listeners. Head to <a href="https://www.timeline.com/promotions/exclusive-offer-for-kris-gethin-community"> timeline.com/GETHIN</a> to get started.</p> <p>LVLUP: Head over to <a href="http://lvluphealth.com/">LVLUPHealth.com</a> and use code GETHIN at checkout to get 20% off.</p> <p> </p> <p dir="ltr"><br> My Go-To for Muscle Building:<br> <br> Isolate + CreGaatine + Dileucine from Unmatched Supplements<br> <a href="https://www.unmatchedsupps.com/collections/muscle-building">https://www.unmatchedsupps.com/collections/muscle-building</a></p> <p dir="ltr">My Go-To for Gut Health:<br> <br> Glutamine and Imuno-IGG from Unmatched Supplements: <a href="https://www.unmatchedsupps.com/collections/digestion-gut-health">https://www.unmatchedsupps.com/collections/digestion-gut-health</a><br> <br></p> <p dir="ltr">Find more from Kris:</p> <p dir="ltr">Website: <a href="https://www.krisgethin.com/">https://www.krisgethin.com/</a>  </p> <p dir="ltr">Instagram: <a href="https://www.instagram.com/krisgethin/">@krisgethin</a> </p> <p dir="ltr">Youtube: <a href="https://www.youtube.com/krisgethin">https://www.youtube.com/krisgethin</a><br> Unmatched Supplements: <a href="https://www.unmatchedsupps.com/">https://www.unmatchedsupps.com/</a></p> <p> </p>