<p>In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The<em> Upgrade Collective</em>! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on <em>The Upgrade Collective</em> membership, and get all sorts of extra biohacking add-ons for your life! </p><p>In today’s episode: <strong>What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress?</strong> Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there! </p><p><br></p><p><strong>What You’ll Learn:</strong> </p><p>• How to naturally boost <strong>oxytocin</strong> for better relationships and emotional health </p><p>• The <strong>fastest way</strong> to upgrade your cold plunge for heat shock benefits </p><p>• Is <strong>rapamycin really a longevity miracle?</strong> Dave’s personal take </p><p>• How <strong>mitochondria impact brain power, mood, and aging</strong>—and how to fix them today! </p><p>• The shocking reason <strong>some people can’t process reality correctly</strong> (and how to retrain your brain) </p><p>• The <strong>real truth about stem cells, exosomes, and V-cells</strong> for regeneration </p><p>• The hidden dangers of <strong>selenium, thyroid supplements, and over-fasting</strong> </p><p><br></p><p>SPONSORS </p><p>-Puori | Visit <a href="https://puori.com/dave" rel="noopener noreferrer" target="_blank">https://puori.com/dave</a> and use code DAVE for 20% storewide.  </p><p>-Calroy | Head to <a href="https://calroy.com/dave" rel="noopener noreferrer" target="_blank">https://calroy.com/dave</a> for an exclusive discount. </p><p> </p><p><strong>Resources:</strong>  </p><p>• <strong>Upgrade Collective Membership</strong>: <a href="https://www.ourupgradecollective.com/" rel="noopener noreferrer" target="_blank">https://www.ourupgradecollective.com</a> </p><p>• <strong>Dave Asprey’s New Book - <em>Heavily Meditated</em>:</strong> <a href="https://daveasprey.com/heavily-meditated/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated/</a> </p><p>• <strong>2025 Biohacking Conference</strong>: <a href="https://biohackingconference.com/2025" rel="noopener noreferrer" target="_blank">https://biohackingconference.com/2025</a> </p><p>• <strong>Danger Coffee</strong>: <a href="https://dangercoffee.com/" rel="noopener noreferrer" target="_blank">https://dangercoffee.com</a> </p><p>• <strong>Dave Asprey’s Website</strong>: <a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com</a> </p><p>• <strong>Dave Asprey’s Linktree</strong>: <a href="https://linktr.ee/daveasprey" rel="noopener noreferrer" target="_blank">https://linktr.ee/daveasprey</a> </p><p>• <strong>Own an Upgrade Labs</strong>: <a href="https://ownanupgradelabs.com/" rel="noopener noreferrer" target="_blank">https://ownanupgradelabs.com</a> </p><p>• <strong>Upgrade Labs</strong>: <a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a> </p><p>• <strong>40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement</strong>: <a href="https://40yearsofzen.com/" rel="noopener noreferrer" target="_blank">https://40yearsofzen.com</a> </p><p><br></p><p><strong>Timestamps:</strong> </p><p>• <strong>00:00</strong> – Intro </p><p>• <strong>00:37</strong> – Welcome to the Human Upgrade AMA </p><p>• <strong>01:13</strong> – Cold Plunges and Alpha Lipoic Acid for Health </p><p>• <strong>03:11</strong> – Hot and Cold Therapy for Optimal Health </p><p>• <strong>07:29</strong> – Understanding Thyroid Health and Treatment </p><p>• <strong>09:09</strong> – The Importance of Selenium </p><p>• <strong>14:41</strong> – Stem Cells vs. Exosomes </p><p>• <strong>16:27</strong> – Rapamycin for Longevity </p><p>• <strong>18:07</strong> – Asperger’s Syndrome and Neuroinflammation </p><p>• <strong>28:53</strong> – Understanding Asperger’s and Self-Awareness </p><p>• <strong>29:24</strong> – The Challenge of Offering Help </p><p>• <strong>30:06</strong> – The Importance of Reconnection Work </p><p>• <strong>31:34</strong> – Personal Development Journey </p><p>• <strong>34:42</strong> – The Role of Emotions in Biohacking </p><p>• <strong>35:55</strong> – Dealing with Flashbacks and Trauma </p><p>• <strong>45:46</strong> – The Power of Oxytocin </p><p>• <strong>49:48</strong> – The Truth About Kale and Oxalates </p><p>• <strong>54:25</strong> – Teaching Kids to Regulate Th