<p>What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? </p><p>Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can <em>bend the rules of biology</em> to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride. </p><p>From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her <strong>Seven Tenets of Aging</strong>. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level. </p><p><strong>What You’ll Learn:</strong> </p><p>• The <strong>Seven Tenets of Aging</strong> and how they’ll change your approach to health </p><p>• Why indulging in “bad” habits doesn’t have to sabotage your longevity </p><p>• Biochemical secrets to combat oxidative stress, glycation, and cellular junk </p><p>• The <strong>real story behind NAD, circadian rhythms, and the tools for better sleep</strong> </p><p>• How to create a personalized health plan that’s sustainable, effective—and fun </p><p><br></p><p><strong>Resources:</strong>  </p><p>• <strong>Supplement Protocol One-Sheet for this episode: </strong><a href="https://www.instagram.com/dave.asprey/?hl=en" rel="noopener noreferrer" target="_blank">https://www.instagram.com/dave.asprey/?hl=en</a></p><p>• <strong>2025 Biohacking Conference</strong>: <a href="https://biohackingconference.com/2025" rel="noopener noreferrer" target="_blank">https://biohackingconference.com/2025</a> </p><p>• <strong>Kaufmann Protocol Website</strong>: <a href="https://kaufmannprotocol.com/" rel="noopener noreferrer" target="_blank">https://kaufmannprotocol.com</a> </p><p>• <strong>Sandra Kaufmann’s Book – Why We Age and How to Stop It:</strong> <a href="https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047" rel="noopener noreferrer" target="_blank">https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047</a> </p><p>• <strong>Sandra Kaufmann’s Instagram:</strong> <a href="https://www.instagram.com/kaufmannantiaging/?hl=en" rel="noopener noreferrer" target="_blank">https://www.instagram.com/kaufmannantiaging/?hl=en</a> </p><p>• <strong>Danger Coffee</strong>: <a href="https://dangercoffee.com/" rel="noopener noreferrer" target="_blank">https://dangercoffee.com</a> </p><p>• <strong>Dave Asprey’s Website</strong>: <a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com</a> </p><p>• <strong>Dave Asprey’s Book – <em>Smarter Not Harder</em></strong>: <a href="https://daveasprey.com/books" rel="noopener noreferrer" target="_blank">https://daveasprey.com/books</a> </p><p>• <strong>Dave Asprey’s Linktree</strong>: <a href="https://linktr.ee/daveasprey" rel="noopener noreferrer" target="_blank">https://linktr.ee/daveasprey</a> </p><p>• <strong>Upgrade Collective – Join The Human Upgrade Podcast Live</strong>: <a href="https://www.ourupgradecollective.com/" rel="noopener noreferrer" target="_blank">https://www.ourupgradecollective.com</a> </p><p>• <strong>Own an Upgrade Labs</strong>: <a href="https://ownanupgradelabs.com/" rel="noopener noreferrer" target="_blank">https://ownanupgradelabs.com</a> </p><p>• <strong>Upgrade Labs</strong>: <a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a> </p><p>• <strong>40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement</strong>: <a href="https://40yearsofzen.com/" rel="noopener noreferrer" target="_blank">https://40yearsofzen.com</a> </p><p><br></p><p> <strong>SPONSORS: </strong> </p><p>Leela Quantum | Head to <a href="https://leelaq.com/DAVE" rel="noopener noreferrer" target="_blank">https://leelaq.com/DAVE</a> for 10% off. </p><p>Timeline | Head to <a href="https://www.timeline.com/dave" rel="noopener noreferrer" target="_blank">https://www.timeline.com/dave</a> to get 10% off your first order. </p><p><br></p><p><strong>Timestamps:</strong> </p><p>• <strong>00:00</strong> Trailer </p><p>• <strong>00:45</strong> Guest Introduction </p><p>• <strong>02:30</strong> Longevity Insights </p><p>• <strong>04:22</strong> Personal Stories </p><p>• <strong>08:00</strong> Pharmaceuticals </p><p>• <strong>12:26</strong> Diet and Lifestyle </p><p>• <strong>18:19</strong> Seven Tenets </p><p>• <strong>22:04</strong> Sleep and Circadian Rhythms </p><p>• <strong>26:41</strong> NAD and Supplements </p><p>• <strong>37:46</strong> Blood Sugar and AGEs </p><p>• <strong>47:09</strong> Microcirculation </p><p>• <strong>49:08</strong> NRS and Imports </p><p>• <strong>49:18</strong> Celeb