In this special episode of The Dr. Tyna Show, I'm tackling the puzzling phenomenon of midlife weight gain—a challenge many of us women face. If you’ve noticed your midsection thickening and overall body changes as you hit middle age, you’re definitely not alone. I’ll break down a recent study on this topic, covering metabolic dysfunction, the role of estrogen, and the impact of physical activity. Join me as I explore the complexities of this stage of life and offer practical solutions, including the benefits of exercise and resistance training. Tune in to uncover the science and get actionable insights for managing your health during this transformative period and learn WHY I think microdosing GLP1 agonists can be such a potent tool in this struggle. On This Episode We Cover: 02:04 - Summarizing the study  07:01 - Metabolic dysfunction in middle aged women  10:03 - The importance of physical activity 11:47 - Disease risk and metabolic syndrome  15:03 - Estrogen, appetite, and physical activity  19:25 - GLP1s, reward pathways, and movement 22:05 - Insulin resistance, mitochondrial and immune dysfunction   25:13 - Testosterone and estrogen rations 26:54 - Adipose tissue dysfunction  28:51 - Obesity, inflammation, and pain  30:11 - Weight affects people differently  33:36 - Therapeutic effects of exercise 35:21 - Insulin resistance 37:43 - The importance of resistance training, HIIT, and yoga  41:52 - Sleep and hormones  44:35 - Study conclusions Sponsored By: BIOptimizers Go to masszymes.com/drtynafree for your first free bottle of Masszymes Maui Nui Use code DRTYNA for 20% off at mauinuivenison.com Show Links: Adipocyte Metabolism and Health after the Menopause: The Role of Exercise Ozempic Done Right University Coupon Code: OUVIP Further Listening EP. 94: For the Men: Master Your Testosterone | Solo Episode EP. 95: Women Need Testosterone, Too | Solo Episode EP. 104: Fatty Liver 101 | Solo Episode EP 106: Ozempic Done Right Part 1 | Solo Episode EP 107: Ozempic Done Right Part 2 | Solo Episode EP. 109: Ozempic Done Right Part 3 | Solo Episode EP. 129: Ozempic Done Right Part 4: Sustained Weight Loss | Solo Episode EP. 132: Ozempic Done Right Part 5: Osteoarthritis + GLP1 Agonists | Solo Episode Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.