<p dir="ltr">Are you protecting your immune system as you age?</p> <p><strong> </strong></p> <p dir="ltr">In this Longevity podcast episode, I am joined by Dr. Anurag Singh to discuss recent research that suggests Urolithin A, a compound derived from pomegranates and other foods, may help rejuvenate the aging immune system. </p> <p><strong> </strong></p> <p dir="ltr">We dive into how supplementing with Urolithin A for just 4 weeks led to significant improvements in immune cell function and a reduction in biological age by an average of 2 years in middle-aged adults. We also discuss insights on dosing, combining Urolithin A with other longevity strategies, and ongoing clinical trials that may reveal even more benefits.</p> <p><strong> </strong></p> <p dir="ltr">Dr. Anurag Singh is the Chief Medical Officer of Timeline Nutrition, a biotech company focused on discovering and developing next generation natural compounds that target improvement in mitochondrial health. He began his career in 2003 as a Resident Medical Doctor at Northern Railway Divisional Hospital in Lucknow. </p> <p><strong> </strong></p> <p dir="ltr">Go to <a href="http://timelinenutrition.com/nat10">TimelineNutrition.com/nat10</a> and/or use code Nat10 for a discount.</p> <p><strong> </strong></p> <p dir="ltr">Thank you to our sponsors for making this episode possible:                                                                                                                                                          </p> <p dir="ltr">Element Health: Use code Longevity when shopping at <a href="https://elementhealthsupply.com/discount/Longevity">https://elementhealthsupply.com/discount/Longevity</a>  to save on your orders.</p> <p dir="ltr">Siphox: Visit <a href="http://siphoxhealth.com/nat">http://SiPhoxhealth.com/nat</a>  and save on your test. </p> <p dir="ltr">                                                                                                                                            </p> <p dir="ltr">Find more from Dr. Singh/Timeline: </p> <p dir="ltr">Website: <a href="http://timelinenutrition.com/nat10">www.timelinenutrition.com</a> </p> <p dir="ltr">Instagram: <a href="https://www.instagram.com/timeline_longevity/">@timeline_longevity</a></p> <p><strong> </strong></p> <p dir="ltr">Find more from Nathalie:</p> <p dir="ltr">YouTube: <a href="https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ">https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ</a> </p> <p dir="ltr">Join Nat’s Membership Community: <a href="https://www.natniddam.com/bsp-community">https://www.natniddam.com/bsp-community</a> </p> <p dir="ltr">Sign up for Nats Newsletter: <a href="https://landing.mailerlite.com/webforms/landing/i7d5m0">https://landing.mailerlite.com/webforms/landing/i7d5m0</a> </p> <p dir="ltr">Instagram: <a href="https://www.instagram.com/nathalieniddam/">https://www.instagram.com/nathalieniddam/</a> </p> <p dir="ltr">Website: <a href="http://www.natniddam.com/">www.NatNiddam.com</a>   </p> <p dir="ltr">Facebook Group: <a href="https://www.facebook.com/groups/biohackingsuperhumanperformance">https://www.facebook.com/groups/biohackingsuperhumanperformance</a> </p> <p><strong> </strong></p> <p dir="ltr">What We Discuss:</p> <p><strong> </strong></p> <p dir="ltr">09:04 The Role of the Immune System in Aging</p> <p dir="ltr">12:10 Understanding Immune Exhaustion and Inflammation</p> <p dir="ltr">15:12 Mitochondrial Health and Immune Function</p> <p dir="ltr">18:06 Urolithin A: Sources and Production</p> <p dir="ltr">12:05 Research Studies on Urolithin A and Cancer</p> <p dir="ltr">30:01 Clinical Trials and Future Directions</p> <p dir="ltr">31:17 Understanding the Immune System</p> <p dir="ltr">33:54 The Mitoimmune Randomized Control Trial</p> <p dir="ltr">38:31 Dosing and Effects of Urolithin A</p> <p dir="ltr">40:22 Biological Age Reversal and Longevity</p> <p dir="ltr">44:33 Combining Strategies for Enhanced Benefits</p> <p dir="ltr">49:21 Future Research Directions in Cancer and Neurodegeneration</p> <p><strong><br> <br></strong></p> <p dir="ltr">Studies Mentioned: </p> <p dir="ltr"><a href="https://www.nature.com/articles/s43587-023-00473-3">Mitochondrial Recycling Reverts Age-Associated Decline</a></p> <p dir="ltr"><a href="https://aacrjournals.org/cancerrescommun/article/4/5/1189/745142/Urolithin-A-Promotes-CD8-T-Cell-mediated-Cancer"> Urolithin-A Promotes CD8+ T Cell–mediated Cancer Immunosurveillance</a></p> <p dir="ltr"><a href="https://pubmed.ncbi.nlm.nih.gov/36351375/">Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy</a></p> <p dir="ltr"><a href="https://drive.google.com/file/d/1NL1DDqZ42dBTMdQzXg8WuizkVDDZ3dAM/view?usp=sharing"> Mitopure Impact on Immune Aging: RCT</a></p> <p> </p>