<p><strong>Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.</strong> </p><p><br></p><p>In this episode of <em>The Human Upgrade</em>, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before. </p><p><br></p><p>You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself. </p><p><br></p><p>Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects. </p><p><br></p><p><strong>What You Will Learn in This Episode:</strong> </p><p>• Why testosterone matters for men and women at every age </p><p>• The real causes of the global testosterone crash </p><p>• Why diet, sleep, and exercise cannot fully fix low testosterone </p><p>• How testosterone drives dopamine, motivation, and longevity </p><p>• The breakthrough that makes oral testosterone safe and effective </p><p>• How Kyzatrex® lowers SHBG and boosts free testosterone naturally </p><p>• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan </p><p>• How to safely use testosterone therapy without suppressing fertility or causing side effects </p><p><br></p><p>** Visit livethrive.com/asprey to get a discount on your first month's supply! ** </p><p><br></p><p><strong>Resources:</strong>  </p><p>• <strong>Dave Asprey’s New Book - <em>Heavily Meditated</em>:</strong> <a href="https://daveasprey.com/heavily-meditated/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated/</a> </p><p>• <strong>Purchase Kyzatrex® –  </strong><a href="https://thesmarthuman.com/" rel="noopener noreferrer" target="_blank">https://thesmarthuman.com/</a> </p><p>• <strong>Shalin’s Instagram - </strong><a href="https://www.instagram.com/themetabolicceo/" rel="noopener noreferrer" target="_blank">https://www.instagram.com/themetabolicceo/</a> </p><p>• <strong>2025 Biohacking Conference</strong>: <a href="https://biohackingconference.com/2025" rel="noopener noreferrer" target="_blank">https://biohackingconference.com/2025</a> </p><p>• <strong>Danger Coffee</strong>: <a href="https://dangercoffee.com/" rel="noopener noreferrer" target="_blank">https://dangercoffee.com</a> </p><p>• <strong>Dave Asprey’s Website</strong>: <a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com</a> </p><p>• <strong>Dave Asprey’s Linktree</strong>: <a href="https://linktr.ee/daveasprey" rel="noopener noreferrer" target="_blank">https://linktr.ee/daveasprey</a> </p><p>• <strong>Upgrade Collective – Join The Human Upgrade Podcast Live</strong>: <a href="https://www.ourupgradecollective.com/" rel="noopener noreferrer" target="_blank">https://www.ourupgradecollective.com</a> </p><p>• <strong>Own an Upgrade Labs</strong>: <a href="https://ownanupgradelabs.com/" rel="noopener noreferrer" target="_blank">https://ownanupgradelabs.com</a> </p><p>• <strong>Upgrade Labs</strong>: <a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a> </p><p>• <strong>40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement</strong>: <a href="https://40yearsofzen.com/" rel="noopener noreferrer" target="_blank">https://40yearsofzen.com</a> </p><p><br></p><p><strong>Timestamps:</strong> </p><p>00:00 Trailer </p><p>00:52 Introduction </p><p>01:29 Global Decline in Testosterone Levels </p><p>02:27 Symptoms of Low Testosterone </p><p>03:48 Personal Journey with Testosterone Therapy </p><p>05:06 The Role of Testosterone in Overall Health </p><p>06:18 Testosterone Levels in Men and Women </p><p>08:48 Challenges and Innovations in Testosterone Delivery </p><p>16:25 The Importance of Circadian Rhythm in Testosterone Therapy </p><p>19:19 The Future of Testosterone Therapy </p><p>32:00 Investment and Development in Testosterone Therapy </p><p>34:57 Introduction to FDA and Hormone Replacement </p><p>35:31 FDA’s Impact on Women’s Health </p><p>36:10 Testosterone and Cardiovascular Risk </p><p>39:05 Testosterone and Depression </p><p>40:30 Testosterone Testing and Misconceptions </p><p>44:58 The Testosterone Project and Female Hormone Therapy </p><p>47:51 Testosterone’s Role in Longevity and Health </p><p>55:37 Cost and Accessibility of Testosterone Therapy </p><p>01:04:03 Conclusion and Final Thoughts </p><p>See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice a