<p>Could a single molecule be the difference between vibrant longevity and early decline? </p><p>Dr. Andy Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor—joins Dave to reveal the <strong>real</strong> key to living longer, fighting disease, and maximizing your energy: <strong>NAD.</strong> </p><p>This master molecule fuels your <strong>mitochondria, DNA repair, and cellular resilience</strong>, but here’s the catch—it <strong>plummets as you age.</strong> That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could <strong>stop the decline and even reverse it?</strong> </p><p>Dr. Salzman breaks down the game-changing science behind <strong>NAD, CD38, and cellular repair</strong>—and the <strong>fastest, most effective ways to optimize your levels for peak performance, health, and longevity.</strong> </p><p>Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the <strong>radical new approach</strong> to living better, longer. </p><p><br></p><p><strong>What You’ll Learn:</strong> </p><p>• <strong>The #1 reason your NAD is disappearing—and how to fix it</strong> </p><p>• <strong>Why NAD is the missing link in energy, DNA repair, and disease prevention</strong> </p><p>• <strong>The hidden enzyme (CD38) that’s sabotaging your longevity</strong> </p><p>• <strong>How to supercharge mitochondria, optimize blood flow, and fight aging at the source</strong> </p><p>• <strong>Why the supplement industry has it wrong—and the best way to boost NAD naturally</strong> </p><p>• <strong>The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine</strong> </p><p><br></p><p><strong>Resources:</strong>  </p><p>• <strong>Dave Asprey’s New Book - <em>Heavily Meditated</em>:</strong> <a href="https://daveasprey.com/heavily-meditated/" rel="noopener noreferrer" target="_blank">https://daveasprey.com/heavily-meditated/</a> </p><p>• <strong>Andrew Salzman’s Instagram – </strong> <a href="https://www.instagram.com/andrew_salzman/?hl=en" rel="noopener noreferrer" target="_blank">https://www.instagram.com/andrew_salzman/?hl=en</a> </p><p>• <strong>2025 Biohacking Conference</strong>: <a href="https://biohackingconference.com/2025" rel="noopener noreferrer" target="_blank">https://biohackingconference.com/2025</a> </p><p>• <strong>Danger Coffee</strong>: <a href="https://dangercoffee.com/" rel="noopener noreferrer" target="_blank">https://dangercoffee.com</a> </p><p>• <strong>Dave Asprey’s Website</strong>: <a href="https://daveasprey.com/" rel="noopener noreferrer" target="_blank">https://daveasprey.com</a> </p><p>• <strong>Dave Asprey’s Linktree</strong>: <a href="https://linktr.ee/daveasprey" rel="noopener noreferrer" target="_blank">https://linktr.ee/daveasprey</a> </p><p>• <strong>Upgrade Collective – Join The Human Upgrade Podcast Live</strong>: <a href="https://www.ourupgradecollective.com/" rel="noopener noreferrer" target="_blank">https://www.ourupgradecollective.com</a> </p><p>• <strong>Own an Upgrade Labs</strong>: <a href="https://ownanupgradelabs.com/" rel="noopener noreferrer" target="_blank">https://ownanupgradelabs.com</a> </p><p>• <strong>Upgrade Labs</strong>: <a href="https://upgradelabs.com/" rel="noopener noreferrer" target="_blank">https://upgradelabs.com</a> </p><p>• <strong>40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement</strong>: <a href="https://40yearsofzen.com/" rel="noopener noreferrer" target="_blank">https://40yearsofzen.com</a> </p><p><br></p><p><strong>Timestamps:</strong> </p><p><strong>00:00</strong> Trailer </p><p><strong>01:07</strong> Introduction and Episode Overview </p><p><strong>02:29</strong> Meet Dr. Andy Salzman </p><p><strong>02:36</strong> From Physician to Researcher </p><p><strong>03:39</strong> Pharmaceuticals vs. Nutritionals </p><p><strong>04:17</strong> The Role of NAD in Longevity </p><p><strong>06:32</strong> Challenges in Longevity Research </p><p><strong>12:58</strong> Understanding NAD and PARP </p><p><strong>14:34</strong> NAD’s Impact on Health </p><p><strong>23:19</strong> Gut Health and Longevity </p><p><strong>27:43</strong> Innovations in NAD Supplementation </p><p><strong>41:27</strong> Customer Feedback and Product Effectiveness </p><p><strong>42:41</strong> Surprising Benefits of NAD for Sexual Health </p><p><strong>44:47</strong> NAD and Vascular Health </p><p><strong>48:46</strong> NAD’s Role in Aging and Longevity </p><p><strong>54:03</strong> NAD and Lifestyle Choices </p><p><strong>01:03:02</strong> NAD and Cognitive Function </p><p><strong>01:06:18</strong> NAD and Exercise </p><p><strong>01:13:42</strong> NAD and Sleep </p><p><strong>01:21:54</strong> Final Thoughts on NAD and Longevity </p><p>See Privacy Policy at <a href="https://art19.com/privacy" rel="noopener noreferrer" target="_blank">https://art19.com/privacy</a> and California Privacy Notice at <a href="https://art19.co