<p>Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.</p><p><br></p><p><strong>This episode covers:</strong></p><p><br></p><p>• <strong>Vitamin D as the Surprising “Anti-Aging Pill”</strong></p><p>A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.</p><p><strong>Source:</strong> Science Daily — <a href="https://www.sciencedaily.com/releases/2025/10/251022023132.htm" rel="noopener noreferrer" target="_blank">https://www.sciencedaily.com/releases/2025/10/251022023132.htm</a></p><p><br></p><p>• <strong>The Supercentenarian Gene That Rejuvenates Old Hearts</strong></p><p>Researchers at the University of Bristol identified a gene variant, <strong>LAV-BPIFB4</strong>, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.</p><p><strong>Source:</strong> University of Bristol News — <a href="https://www.bristol.ac.uk/news/2025/october/progeria.html" rel="noopener noreferrer" target="_blank">https://www.bristol.ac.uk/news/2025/october/progeria.html</a></p><p><br></p><p>• <strong>FDA Closes the “GRAS” Loophole — Supplements Enter a New Era</strong></p><p>The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.</p><p><strong>Source:</strong> Mintz FDA Flux Newsletter — <a href="https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter" rel="noopener noreferrer" target="_blank">https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter</a></p><p><br></p><p>• <strong>Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch</strong></p><p>Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.</p><p><strong>Source:</strong> University of Basel — <a href="https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research---Dietary-stress-supports-healthy-aging.html" rel="noopener noreferrer" target="_blank">https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html</a></p><p><strong>Further reading:</strong> Neuroscience News — <a href="https://neurosciencenews.com/dietary-rna-cellular-aging-29757/" rel="noopener noreferrer" target="_blank">https://neurosciencenews.com/dietary-rna-cellular-aging-29757/</a></p><p><br></p><p>• <strong>Your Medical Avatar Is Coming — The Digital Twin of You</strong></p><p>Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it <em>generative health</em> — a revolution in predictive medicine where your data literally becomes your doctor.</p><p><strong>Source:</strong> Forbes Innovation — <a href="https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/" rel="noopener noreferrer" target="_blank">https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/</a></p><p><br></p><p>This is essential listening for fans of <strong>biohacking, human performance, functional medicine, and longevity science</strong>who want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.</p><p><br></p><p>With over 1,000 interviews and 1 million monthly listeners, <strong>The Human Upgrade</strong> brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.</p><p><br></p><p><strong>New episodes</strong> drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.</p><p><br></p><p><strong>Keywords:</strong> vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foo