<p>This week on <em>Fat Science</em>, Dr. Emily Cooper, Andrea Taylor, and Mark Wright answer listener questions from around the world about metabolic health. This mailbag episode explores widely-debated topics like “starvation mode,” weight loss plateaus, the relationship between metabolism and cognitive health, cannabis and metabolism, metabolic effects of liposuction, and the latest on GLP-1 medications.</p><p><br></p><p><strong>Key Takeaways:</strong></p><ul><li>Dr. Cooper dispels myths around “starvation mode,” citing research on the long-term metabolic impact of dieting and caloric restriction.</li><li>Weight loss plateaus are often misunderstood—Dr. Cooper explains the natural adaptations behind them and how to assess true progress.</li><li>Metabolic health plays a major role in brain function, cognitive decline, depression, and dementia prevention.</li><li>Cannabis affects metabolic pathways in complex ways, with regular use potentially causing negative metabolic effects.</li><li>Liposuction can trigger metabolic rebound and rapid fat regain for some patients, especially when leptin levels are low.</li><li>Updates on GLP-1 meds: Liraglutide is available in generic form, but costs fluctuate. New oral and combination therapies are on the horizon.</li></ul><p><strong>Personal Stories & Practical Advice:</strong></p><ul><li>Andrea and Mark reflect on their own journeys with dieting, weight plateaus, and medication.</li><li>Dr. Cooper shares clinical experiences with metabolic rebound after liposuction and ways to navigate pharmacologic treatments.</li></ul><p><strong>Resources:</strong></p><ul><li>Connect with Dr. Emily Cooper on <a href="https://www.linkedin.com/in/emily-cooper-md-072778/">LinkedIn.</a></li><li>Connect with Mark Wright on <a href="https://www.linkedin.com/in/mark-wright-media/">LinkedIn</a>.</li><li>Connect with Andrea Taylor on <a href="https://www.instagram.com/andreatay323/">Instagram</a>.</li></ul><p><em>Fat Science</em> is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.</p><p>If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at <a href="mailto:[email protected]">[email protected]</a> or <a href="mailto:[email protected]">[email protected]</a><u>.</u></p><p>Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. <a href="https://diabesityresearchfoundation.org/">https://diabesityresearchfoundation.org/</a></p>